Autophagy in Cardiac Development

Main Article Content

Hongxin Zhu Lin He

Abstract

The heart is the first functional organ to form during embryogenesis. Cardiac development is a multifactorial complex process requiring precise control of proliferation, differentiation, migration and survival of diverse cell types by interactive networks of genetic and environmental factors. Autophagy is a conserved catabolic pathway that degrades cytoplasmic contents in lysosomes for reutilization. It is well established that autophagy regulates the development of nervous system, osseous tissue, adipose tissue and lymphocyte. Recent evidences on the basis of in vitro cell culture systems as well as in vivo animal models suggest essential roles of autophagy in cardiogenesis. In this review, we summarize the major findings regarding emerging roles of autophagy and autophagy-related genes in cardiac development, which implicates autophagy in human congenital heart disease, the leading human birth defect worldwide.

Article Details

How to Cite
ZHU, Hongxin; HE, Lin. Autophagy in Cardiac Development. Medical Research Archives, [S.l.], v. 5, n. 3, mar. 2017. ISSN 2375-1924. Available at: <https://journals.ke-i.org/mra/article/view/1114>. Date accessed: 04 aug. 2020.
Keywords
Autophagy; Cardiac development; Congenital heart disease
Section
Review Articles

Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.