Potassium channels in pancreatic cancer
Main Article Content
Abstract
Pancreatic duct adenocarcinoma accounts for approximately 90% of pancreatic cancers and has a very poor prognosis. Several K+ channels have been suggested as hallmarks for adenocarcinoma. This review focuses on molecular candidates of functional K+ channels in pancreatic adenocarcinoma, including KCNN4 (KCa3.1), KCNJ3 (Kir3.1), KCNA3 (Kv1.3), KCNA5 (Kv1.5), KCNH1 (Kv10.1), and KCNK5 (K2P5.1). We provide an overview of K+ channels with respect to their electrophysiological and pharmacological characteristics and tissue expression, in addition to their identification and functions in pancreatic adenocarcinomas. We conclude by discussing some outstanding questions and future directions in pancreatic K+ channel research with respect to the treatment of pancreatic cancer.
Article Details
How to Cite
HAYASHI, Mikio; MATSUDA, Hiroko.
Potassium channels in pancreatic cancer.
Medical Research Archives, [S.l.], n. 4, aug. 2016.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/600>. Date accessed: 20 apr. 2024.
Keywords
cancer; EAG1; GIRK1; pancreas; SK4; TASK-2
Issue
Section
Review Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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7. Brevet M, Fucks D, Chatelain D, Regimbeau JM, Delcenserie R, Sevestre H, et al. Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of Kv1.3 gene promoter methylation. Pancreas 2009; 38:649-54. doi:10.1097/MPA.0b013e3181a56ebf
8. Brüggemann A, Pardo LA, Stühmer W, Pongs O. Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP. Nature 1993; 365:445-8. doi:10.1038/365445a0
9. Castle NA, London DO, Creech C, Fajloun Z, Stocker JW, Sabatier JM. Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels. Mol Pharmacol 2003; 63:409-18. doi:10.1124/mol.63.2.409
10. Cazals Y, Bévengut M, Zanella S, Brocard F, Barhanin J, Gestreau C. KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing. Nat Commun 2015; 6:8780. doi:10.1038/ncomms9780
11. Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 2001; 39:1269-76. doi:10.1016/S0041-0101(01)00120-9
12. Chittajallu R, Chen Y, Wang H, Yuan X, Ghiani CA, Heckman T, et al. Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle. Proc Natl Acad Sci U S A 2002; 99:2350-5. doi:10.1073/pnas.042698399
13. Chung I, Schlichter LC. Native Kv1.3 channels are upregulated by protein kinase C. J Membr Biol 1997; 156:73-85. doi:10.1007/s002329900189
14. Cotten JF, Zou HL, Liu C, Au JD, Yost CS. Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2). Brain Res Mol Brain Res 2004; 128:112-20. doi:10.1016/j.molbrainres.2004.06.007
15. Fong P, Argent BE, Guggino WB, Gray MA. Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF. Am J Physiol Cell Physiol 2003; 285:C433-45. doi:10.1152/ajpcell.00509.2002
16. Franqueza L, Longobardo M, Vicente J, Delpón E, Tamkun MM, Tamargo J, et al. Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels. Circ Res 1997; 81:1053-64. doi:10.1161/01.RES.81.6.1053
17. Franqueza L, Valenzuela C, Delpón E, Longobardo M, Caballero R, Tamargo J. Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels. Br J Pharmacol 1998; 125:969-78. doi:10.1038/sj.bjc.0702129
18. García-Ferreiro RE, Kerschensteiner D, Major F, Monje F, Stühmer W, Pardo LA. Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J Gen Physiol 2004; 124:301-17. doi:10.1085/jgp.200409041
19. Gerlach AC, Gangopadhyay NN, Devor DC. Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1. J Biol Chem 2000; 275:585-98. doi:10.1074/jbc.275.1.585
20. Gomez-Lagunas F, Carrillo E, Pardo LA, Stühmer W. Gating Modulation of the Tumor-Related Kv10.1 Channel by Mibefradil. J Cell Physiol 2016. doi:10.1002/jcp.25448.
21. Gómez-Varela D, Zwick-Wallasch E, Knötgen H, Sánchez A, Hettmann T, Ossipov D, et al. Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res 2007; 67:7343-9. doi:10.1158/0008-5472.CAN-07-0107
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