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The literature surrounding oral antihypertensive desensitization procedures is limited. Desensitization is a therapeutic option for many medications but little information exists for anti-hypertensives, and no information exists for valsartan.
A 55-year-old man developed hypersensitivity reactions to several antihypertensive medications, including valsartan. Multiple attempts were made trialing numerous anti-hypertensives. A 17-step rapid sequential oral desensitization procedure to valsartan was performed in this patient with successful tolerance and an absence of hypersensitivity reactions which led to adherence and chronic blood pressure control.
To our knowledge this is the first report of valsartan desensitization. This successful intervention allowed for the patient to continue taking an essential antihypertensive medication necessary for optimal blood pressure control. The intention of this report is to help guide the management of complex patients who require desensitization to valsartan and to other antihypertensives in the future.
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