The potential role of the paxillin paralog Hic-5 in progression of hepatocellular carcinoma
Main Article Content
Abstract
Hepatocellular carcinoma (HCC) is one of the most common causes of death from cancer worldwide. The poor prognosis of HCC is due to high recurrence rate mainly caused by intrahepatic metastasis. Paxillin was known to be a central adaptor protein for mediating focal adhesion (FA) signal required for HCC progression. However, target therapy aiming at paxillin seems unfeasible due to its ubiquitous tissue expression and essential biological functions. Within the paxillin superfamily, hydrogen peroxide inducible clone-5 (Hic-5) is the most homologous to paxillin. This review summarises the recent findings relevant to the differential biochemical and biological roles of Hic-5 and paxillin. Given the structure similarity between Hic-5 and paxillin, Hic-5 shares many of the characteristics of paxillin, including the localization of Hic-5 at focal adhesions and similar FA binding factors. However, some of the regulatory mechanisms and molecular functions of Hic-5 are rather different from those of paxillin. These might explain the differential roles of both adaptors in regulating various pathophysiological processes. Interestingly, both adaptors might play distinct but complementary roles in tumor progression. Due to the more limited tissue distribution of Hic-5, it can be a more suitable therapeutic target for preventing HCC progression.
Keywords:
Hepatocellular carcinoma, Metastasis, Paxillin, Hic-5, focal adhesions
Article Details
How to Cite
WU, Wen-Sheng et al.
The potential role of the paxillin paralog Hic-5 in progression of hepatocellular carcinoma.
Medical Research Archives, [S.l.], v. 6, n. 3, mar. 2018.
ISSN 2375-1924.
Available at: <https://esmed.org/MRA/mra/article/view/1702>. Date accessed: 20 apr. 2024.
doi: https://doi.org/10.18103/mra.v6i3.1702.
Section
Research Articles
The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.
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