VCAM-1 Mediates Cigarette Smoke Extract Enhancement of Monocyte Adhesion to Human Carotid Vascular Endothelial Cells.

Main Article Content

Greg B. Pott Mark Tsurudome Jamie Bui Charles Banfield Sami Hourieh Harsh Pratap Marc L. Goalstone

Abstract

 

Atherosclerosis is a cardiovascular disease that begins with inflammation and ends in decreased lumen diameter, occlusion and rupture if not addressed appropriately.  Markers of vascular inflammation are, but not limited to, increased expression of Cell Adhesion Molecules on the vascular endothelium, recruitment of serum monocytes to the endothelium, and increases in the presence of inflammatory cytokines.  Many factors can contribute to vascular inflammation and atherosclerosis, including diabetes, obesity, smoking, and genetic factors. In this report, we examine how cigarette smoke extract (CSE) contributes to the onset of vascular inflammation by (1) increasing VCAM-1 and ICAM-1 expression in endothelium in a time- and dose-dependent manner, (2) affecting cytokine expression in endothelial cells, (3) increasing monocyte adhesion to carotid endothelial cells and (4) increasing the number of monocytes that migrate across a monolayer of carotid endothelial cells.

 

Article Details

How to Cite
POTT, Greg B. et al. VCAM-1 Mediates Cigarette Smoke Extract Enhancement of Monocyte Adhesion to Human Carotid Vascular Endothelial Cells.. Medical Research Archives, [S.l.], v. 5, n. 7, july 2017. ISSN 2375-1924. Available at: <https://journals.ke-i.org/index.php/mra/article/view/1398>. Date accessed: 18 jan. 2019.
Keywords
cigarette smoke extract, monocytes, carotid endothelial cells
Section
Research Articles

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