Synthesis of 6-(4-methanesulphonamidophenyl)-substituted dihydropyridazinone/ phthalazinone derivatives as potent anti-inflammatory and analgesic agents

Main Article Content

Deepika Sharma Dinesh Kumar Ranju Bansal

Abstract

New 6-(4-methanesulphonamidophenyl)-substituted dihydropyridazinones and their phthalazinone analogues have been synthesized and evaluated for anti-inflammatory and analgesic activities using carrageenan induced paw edema and acetic acid induced writhing models, respectively. Most of the newly synthesized compounds displayed potent anti-inflammatory activity without ulcerogenic side effects. Both pyridazinone as well as phthalazinone analogues displayed moderate analgesic activity at 40 mg/kg. In general, all pyridazinone derivatives showed activity better than their phthalazinone counterparts.

Article Details

How to Cite
SHARMA, Deepika; KUMAR, Dinesh; BANSAL, Ranju. Synthesis of 6-(4-methanesulphonamidophenyl)-substituted dihydropyridazinone/ phthalazinone derivatives as potent anti-inflammatory and analgesic agents. Medical Research Archives, [S.l.], n. 1, dec. 2014. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/13>. Date accessed: 29 mar. 2024.
Keywords
3(2H)-pyridazinones, phthalazinones, analgesics, anti-inflammatory 3(2H)-pyridazinones, phthalazinones, analgesics,anti-inflammatory agents, ulcerogenic effect
Section
Research Articles

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