Final results of a prospective treatment program for chronic viral Hepatitis B and C: Health Services Development Program (HSDP)

Main Article Content

Thwin Maung Aye Seng Gee Lim Myat Oo Aung Kieron Lim Yin Mei Lim Guan Huei Lee How Cheng Low Yock Young Dan

Abstract

Background and Aims: Chronic Hepatitis B (CHB) and C (CHC) lead to chronic liver disease and complications if left untreated. A Health Services Development Program (HSDP) was approved by the Ministry of Health to evaluate the effectiveness of treatment and the outcomes of CHB and CHC.

Methods: Eighty-three CHB and twenty-one CHC patients were included. Inclusion criteria were HBVDNA>105 copies/ml, abnormal Liver Function Tests (LFTs), cirrhosis and positive HCVRNA. Daily Lamivudine with/without Adefovir rescue therapy and pegylated interferon with ribavirin were prescribed. Exclusion criteria were hepatocellular carcinoma, renal failure, CHB/CHC/HIV co-infection. Outcomes measured were: proportion of patients who i) normalize LFTs, ii) achieve sustained virological remission, iii) improve Child-Pugh (CP) score, iv) develop liver related complications and v) die.

Results: CHB: Thirty-one patients (37%) had baseline cirrhosis. The mean therapy duration was 67.5 months. At the end of study, 100% had undetectable HBVDNA and 98% had LFTs normalization. The majority (87%) had stable C-P score, of whom 11.42% had improvement of score >2 points. Lamivudine resistance developed in 59.5% requiring add-on Adefovir therapy. Eleven patients (13%) developed end stage liver disease complications. CHC: There were 21 patients (genotype1=62%). Eight patients (38%) had baseline cirrhosis. LFTs improved in 18 patients (86%). The overall end-of-treatment response and SVR were 95% and 86% while SVR for genotype 1 and 2/3 were 92% and 75% respectively. No major liver related complications or mortality were noted.

Conclusion: It was a successful program with excellent outcomes of disease complication free in 87% of  CHB patients.

Article Details

How to Cite
AYE, Thwin Maung et al. Final results of a prospective treatment program for chronic viral Hepatitis B and C: Health Services Development Program (HSDP). Medical Research Archives, [S.l.], n. 3, may 2015. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/127>. Date accessed: 28 mar. 2024.
Keywords
Hepatitis treatment; lamivudine; adefovir; clinical outcomes; liver cirrhosis; HCC
Section
Research Articles

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