Concomitant sorting of circulating tumor cell subpopulations in cancer patients’ blood samples through the multiplexed-immunosensor combination design

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Phuong Lan Tran Yohann Tendero François Goldwasser Stanislas Ropert Romain Coriat

Abstract

Tumor cells that circulate in blood can initiate tumor metastases in distant sites. Circulating tumor cells (CTCs) are rare and heterogeneous, and display various phenotypes. The molecular characterization of each subpopulation is fundamental to its phenotypic identification and description of relevant genetic alterations for the management of patient's disease. We have previously described the development of a new mesofluidic multiplexed-immunosensor device for the capture and analysis of CTCs from blood samples of breast cancer patients. To aid sorting cancer cell subtypes for their characterization, we improve our methodology by serially interconnecting three-designed multiplexed-immunosensor devices that allowed grafting a subset of selective and specific antibodies for the capture of each cancer cell subtype. This new method gives a powerful tool to identify circulating tumor cell subtypes.

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How to Cite
TRAN, Phuong Lan et al. Concomitant sorting of circulating tumor cell subpopulations in cancer patients’ blood samples through the multiplexed-immunosensor combination design. International Biology Review, [S.l.], v. 2, n. 2, june 2018. ISSN 2572-7168. Available at: <https://journals.ke-i.org/index.php/ibr/article/view/1782>. Date accessed: 22 july 2019. doi: https://doi.org/10.18103/ibr.v2i2.1782.
Section
Research Articles

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