Nuclear Receptors as Potential Pharmacological Targets for Colorectal Cancer Therapy via Regulating Wnt/β-catenin Signaling

Main Article Content

Tianhui Hu Jihuan Hou Xiaolin Xu Yanyan Zhan

Abstract

Hyperactivation of the Wnt/β-catenin signaling pathway due to mutations in its components initiates the majority of colorectal cancer (CRC) cases and promotes CRC development. Unphosphorylated β-catenin accumulates in the nuclear and interacts with TCF/LEF factors to stimulate the transcription of the downstream target genes of Wnt/β-catenin signaling. Therefore, the suppression of dysregulated Wnt/β-catenin signaling is considered as a promising strategy for CRC therapy. In the past decade, accumulating evidence revealed that nuclear receptors (NRs) modulated Wnt/β-catenin signaling activity via binding to diverse members of this pathway. In this review, we mainly focus on the regulation and the underlying mechanisms of Wnt/β-catenin signaling by NRs and their ligands or pharmacological modulators. Their potential in the precise treatment and individualized therapy for colorectal cancer is also discussed.

Article Details

How to Cite
HU, Tianhui et al. Nuclear Receptors as Potential Pharmacological Targets for Colorectal Cancer Therapy via Regulating Wnt/β-catenin Signaling. Medical Research Archives, [S.l.], v. 4, n. 7, nov. 2016. ISSN 2375-1924. Available at: <http://journals.ke-i.org/index.php/mra/article/view/812>. Date accessed: 20 jan. 2018.
Section
Review Articles

References

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