Validity of a Newly Developed Noninvasive Method for Estimating Cerebral Blood Flow Using 123I-IMP Acquisition Data from the Lungs and Brain

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Published Oct 16, 2016

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Yusuke Fujita
Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine
Shinji Abe
Departoment of Radiological Technology, Nagoya University Hospital
Tetsuro Odagawa
Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine
Arisa Niwa
Departoment of Radiological Technology, Nagoya University Hospital
Saki Tsuchiya
Departoment of Radiological Technology, Nagoya University Hospital
Yumiko Koshiba
Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine
Naotoshi Fujita
Departoment of Radiological Technology, Nagoya University Hospital
Hidetaka Kono
Departoment of Radiological Technology, Nagoya University Hospital
Seiichi Yamamoto
Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine
Katsuhiko Kato
Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine
http://orcid.org/0000-0002-2083-9319

Abstract

Objective: Previously we devised a method for estimating 123I-IMP activity at 10 min after intravenous injection of 123I-IMP (Ca10) without any blood sampling using 123I-IMP autoradiography (ARG) acquisition data, and verified its usefulness for quantification of the regional cerebral blood flow (rCBF). In this study, we attempted to develop a more simplified method for estimation of Ca10 and to validate its usefulness for quantification of rCBF in a number of patients with different cerebrovascular diseases.

Methods: Consecutive 134 patients were examined for 123I-IMP ARG study. Dynamic images of the lungs for 5 min and brain SPECT images for 30 min (6×5 min) and Ca 10 values were acquired from the first 35 patients. Using the data of the 35 patients, the regression equation for estimating Ca10 was calculated by the multiple regression analysis. The regression equation was applied to the other 99 patients who comprised 29 patients with Parkinson’s disease, 32 with common or internal carotid artery occlusion or stenosis, 14 with moyamoya disease, 12 with cerebral infarction, and 12 with other diseases. The mean of rCBFs in various regions of the brain (mCBF) calculated using the estimated Ca10 was compared with that calculated using directly measured Ca10 in the 99 patients. 

Results: The regression equation obtained was as follows: Estimated Ca10 =1070.1 +2.17 ×10-3a-8.08 ∙ b - 2.23 ×c +2.47 ×10-3d, where a: the area under the time-activity curve of the lungs (UCL), b: body weight, c: sum of UCL and the counts of brain projection data from 10 to 15 min after injection (CB1), d: those from 35 to 45 min (CB6), respectively. The estimated Ca10 closely correlated with the directly measured Ca10 (r=077). The mCBF values calculated using the estimated Ca10 closely correlated with those calculated using the directly measured Ca10 in all the patient groups (r=0.80, 0.78, 0.62, 0.77, 0.85 and 0.79 in patients with Parkinson’s disease, common or internal carotid artery occlusion or stenosis, moyamoya disease, cerebral infarction, and the other diseases, and total 99 patients, respectively).  

Conclusion: This study verified that the newly developed noninvasive method, which is more simplified than the previous method, can estimate reliably the Ca10 values which are available for quantification of rCBF in different patient groups.

 

Article Details

How to Cite
FUJITA, Yusuke et al. Validity of a Newly Developed Noninvasive Method for Estimating Cerebral Blood Flow Using 123I-IMP Acquisition Data from the Lungs and Brain. Medical Research Archives, [S.l.], v. 4, n. 6, oct. 2016. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/634>. Date accessed: 18 apr. 2024.
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Keywords
the regional cerebral blood flow (rCBF), 123I-IMP, Ca10, SPECT.
Issue
Vol 4 No 6 (2016): Vol. 4 issue 6, October,2016
Section
Research Articles

The Medical Research Archives grants authors the right to publish and reproduce the unrevised contribution in whole or in part at any time and in any form for any scholarly non-commercial purpose with the condition that all publications of the contribution include a full citation to the journal as published by the Medical Research Archives.

 

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