A 29 year old female presenting with a gastric schwannoma: a case presentation and review of the literature

Main Article Content

Lemuel Dent

Abstract

Schwannomas or neurilemmoma are benign, slow-growing, encapsulated nerve-sheath tumors arising from Schwann cells.Schwannomas are benign mesenchymal tumors composed of spindle cells and are included in the differential diagnosis along with gastrointestinal stromal tumors (GIST), leiomyomas, and leiomyosarcomas. Schwannomas have a peak incidence in the 4th and 5th decades of life, are slightly more common in females, and represent 0.2% of all gastric tumors and 4% of all benign gastric neoplasms. Since radiographic, endoscopic findings are nonspecific, the diagnosis of schwannoma depends upon immunohistochemical analysis including positive S100 protein and abscence of C-Kit, CD34, and CD 117. GIST has malignant potential thus it is important to distinguish between GIST and schwannoma.The majority of patients with schwannoma remain asymptomatic for extended periods, with most cases discovered incidentally on imaging or laparotomy. We present a case of gastric schwannoma, which is unusual due to the patient’s young age, and the early onset of symptoms of abdominal pain and nausea. Though unusual for young patients, gastric schwannomas should be considered in the differential diagnosis when submucosal gastric masses are detected on preoperative imaging studies. Complete resection with negative margins is the treatment of choice for gastric schwannomas. 

Article Details

How to Cite
DENT, Lemuel. A 29 year old female presenting with a gastric schwannoma: a case presentation and review of the literature. Medical Research Archives, [S.l.], n. 4, aug. 2016. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/551>. Date accessed: 29 mar. 2024.
Keywords
schwannoma, benign gastrointestinal tumors
Section
Case Reports

References

. REFERENCES
1. H. Menno, M. Cathelijne, Z. Plantes, et al., Gastric schwannoma presenting as an incidentaloma on CT-scan and MRI, Gastroenterology Research. 3(6) (2010) 276-280. doi:10.4021/gr2y5w

2. V. Darrouzet, J. Martel, V. Enee, et al., Vestibular schwannoma surgery outcomes: our multidisciplinary experience in 400 cases over 17 years, Laryngoscope 114 (2004) 681-688. PMID:15064624

3. R. Whitehead, Gastrointestinal and Oesophageal Pathology, 2nd ed. New York: Churchill Livingston. (1989) 727-39.

4. M. Miettinen, K. Shekitka, L. Sobin, Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases, Am J Surg Pathol. 25 (2001) 846-855. PMID:11420455

5. W. Melvin, M. Wilkinson, Gastric schwannoma: clinical and pathologic considerations. Am Surg. 59(5) (1993) 293-296. PMID:8489097

6. M. Sarlomo-Rikala, M. Miettinen, Gastric schwannoma: a clinicopathological analysis of 6 cases, Histopathol. 27 (1995) 355-36 PMID:8847066

7. C. Lin, H. Hsu, C. Tsai, et al., Gastric schwannoma, J Chin Med Assoc, 67 (2004) 583-586. PMID:15720074

8. A. Agaimy, B. Märkl, J. Kitz, et al., Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1 associated gastric schwannoma and unusual morphologic variants, Varchows Arch. 426 (2010) 411- 422. doi:10.1007/s00428-010-0886 PMID:20155280

9. L. Voltaggio, R. Murray, J. Lasota, et al., Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature, Hum Pathol. 43(5) (2012) 650-659. doi:10.1016/J.humpath.2011.07.006 PMID:22137423

10. Y. Daimaru, H. Kido, H. Hashimoto, et al., Benign schwannoma of the gastrointestinal tract: a clinicopathologic and immunohistochemical study, Hum Pathol. 19 (1988) 257-264. PMID:3126126

11. A. Levy, A. Quiles, M. Miettinen, et al., Gastrointestinal Schwannomas. CT Features with clinicopathologic correlation, AJR 184 (2005) 797-802. PMID:15728600

12 http://surgpathcriteria.stanford.edu/gitumors/schwannoma/
13. M. Su, F. Mong, Gastric schwannoma: Case report and literature review, J Med Sci. 32(5) (2012) 247-250. PMID: 26405419

14. A. Watanabe, H. Ojima, S. Suzuki, et al., An individual with gastric schwannoma with pathologically malignant potential surviving two years after laparoscopy-assisted partial gastrectomy, Case Reports in Gastroenterology. 5 (2011) 502-507. doi:10.1159/000331561 PMID:21850386

15. U. Serife, K. Zafer, Radiologic findings in malignant gastrointestinal stromal tumors, Diagn IntervRadiol.
15 (2009) 121-126. PMID: 19517382

16. N. Bees, C. Ng, C. Dicks-Mireaux, et al., Gastric malignant schwannoma in a child, Br J Radiol.
70 (1997) 952-955. PMID: 9486074 DOI: 10.1259/bjr.70.837.9486074

17. S. Weiss, J. Langloss, F. Enjinger, Value of S-100protein in the diagnosis of soft tissue tumors with
particular reference to benign and malignant Schwann cell tumors, Lab Invest. 49 (1983) 1052-1054.
PMID: 6310227