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Synthesis of 6-(4-methanesulphonamidophenyl)-substituted dihydropyridazinone/ phthalazinone derivatives as potent anti-inflammatory and analgesic agents

Deepika Sharma, Dinesh Kumar, Ranju Bansal


New 6-(4-methanesulphonamidophenyl)-substituted dihydropyridazinones and their phthalazinone analogues have been synthesized and evaluated for anti-inflammatory and analgesic activities using carrageenan induced paw edema and acetic acid induced writhing models, respectively. Most of the newly synthesized compounds displayed potent anti-inflammatory activity without ulcerogenic side effects. Both pyridazinone as well as phthalazinone analogues displayed moderate analgesic activity at 40 mg/kg. In general, all pyridazinone derivatives showed activity better than their phthalazinone counterparts.


3(2H)-pyridazinones, phthalazinones, analgesics, anti-inflammatory 3(2H)-pyridazinones, phthalazinones, analgesics,anti-inflammatory agents, ulcerogenic effect

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DOI: http://dx.doi.org/10.18103/mra.v0i1.13


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