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Attenuating the coagulation cascade with annexin A5

James Kennedy

Abstract


Membrane displayed phosphatidylserine (PS) on platelets, microparticles, endothelial cells and erythrocytes is the platform for the coagulation cascade and annexin A5’s great affinity for PS allows it to bind to it and form a shield that can block the cascade. In spite of this significant anticoagulant ability annexin A5 has no therapeutic anticoagulant application. Why?  


Keywords


phosphatidylserine, annexin A5, infarct, protein C, coagulation

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References


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DOI: http://dx.doi.org/10.18103/mra.v0i3.113

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