TY - JOUR AU - Ohguro, Hiroshi AU - Watanabe, Megumi AU - Inatomi, Shuichiro AU - Umeda, Kazushi AU - Ohguro, Ikuyo PY - 2015 TI - A simple method for evaluation of aqueous humor dynamics “A weight on-off test” in patients with glaucom JF - Medical Research Archives; No 3 (2015) KW - aqueous humor ; glaucoma ; intraocular pressure ; tonography N2 - Purpose : To evaluate aqueous humor (AH) dynamics in patients with glaucoma through a newly developed method termed the “Weight on-off test” Methods : Patients: primary open angle glaucoma (POAG) (n=124), primary angle closure glaucoma ( n=16), Pseudoexfoliation syndrome ( n=17), or senile cataract (n=93) without other eye diseases. For evaluation of AH dynamics, a 50 g weight was placed onto the eye of a subject in a supine position for 5 min and then removed . Intraocular pressure ( IOP) was measured before and immediately after removal, and thereafter every minute until IOP returned to baseline . Based upon IOP changes (decreases during the weight on and recovery after removal), we defined AH outflow resistance : IOP drop rate (IOP drop ) (%) = (P 0 -P e ) – (P 5 -P e ) / (P 0 -P e ) x 100 (P 0 : IOP at baseline, P e : assumed episcleral venous pressure , P 5 : IOP at 5 min) and AH outflow resistance index (R aq out ) = 100 - IOP drop , and AH production : IOP recovery time (IOP rec ) (min) reached to baseline IOP, and AH production index (P aq ) was an IOP increase rate during the IOP rec by least squares method. Results: AH outflow resistance was significantly higher in glaucoma subjects than the control. AH production in glaucoma subjects was slightly increased compared to that in control. In POAG, prostaglandin-analogues (PG) caused a significant delay of AH production ( IOP rec ). Conclusions: The current data suggests that a “Weight on-off test” may be simple and useful for estimating AH dynamics in patients with glaucoma and provides a better understanding of glaucoma etiology as well as its pharmacology. UR - https://esmed.org/MRA/mra/article/view/227