%A Spaeth, Brooke Ann %A Shephard, Anne K %A Shephard, Mark DS %A Mathew, Timothy H %D 2015 %T Assessment of a point-of-care device for measuring creatinine in a community screening program for chronic kidney disease %K chronic kidney disease; point-of-care testing; creatinine; estimated glomerular filtration rate %X ABSTRACT   Background: Chronic kidney disease (CKD) is a major contemporary global health problem. Creatinine measurement for the calculation of estimated glomerular filtration rate is an important component of assessing CKD risk. A point-of-care test for creatinine using capillary sampling is required as part of a screening assessment.   Objectives: Evaluate the analytical performance of a modified point-of-care testing method for whole blood creatinine (Nova Biomedical StatSensor whole blood creatinine analyser) relative to a laboratory method.   Design and methods: Conduct a patient comparison study between the point-of-care testing and laboratory methods in a rural community setting. Calculate measures of imprecision and assess the ability of the POCT method to determine staging of CKD compared to the laboratory.   Results: Between-device imprecision averaged 8.8%. The StatSensor devices showed a positive bias of approximately 14% for whole blood creatinine measurement compared to the laboratory method, leading to more than 40% of community patients being staged differently for CKD risk with approximately 25% more abnormal results.   Conclusions: The StatSensor whole blood creatinine point-of-care device remains analytically unsound for use as a screening device for CKD. %U https://esmed.org/MRA/mra/article/view/132 %J Medical Research Archives %0 Journal Article %N 3 %@ 2375-1924 %8 2015-05-18