Dr. Nandan Kumar Mondal
I am an Assistant Professor (tenure-track) in the Departments of Cardiovascular & Thoracic Surgery at the University of Louisville (UofL). I am also a part of the Advanced Heart Failure Research program in the Cardiovascular Innovation Institute (CII). I joined the CII as a Postdoctoral Associate through the Cardiovascular and Thoracic Surgery Department in December 2014. Since coming to UofL, I am extensively working on the contentious-Flow Left Ventricular Assist Device (CF-LVAD) associated clinical complications especially bleeding, infection and stroke; and identified several biomarkers of non-physiological high shear induced blood cell dysfunction. I have approximately a decade’s worth of experience in the field of human as well as animal biology. In India, I had a broad background in hematology since 2007, with specific training and expertise in key research areas (blood damage and platelet biology etc.). During the period of 2007 to 2011, I had successfully completed many research projects in India including ‘indoor air pollution and women’s health’, ‘drug abuse and child health’ and ‘occupational public health’. I came to University of Maryland School of Medicine, Baltimore in 2012 from India, where for the previous two years I was on faculty (Assistant Professor) at the Department of Zoology, Kabi Nazrul College of The University of Burdwan, India. As a postdoctoral researcher at the Department of Surgery, University of Maryland, I became acquainted not only with human subject research but also with GLP standard animal studies. My expertise include but are not limited to different techniques of molecular biology, recruitment of participants and patients in the research protocol, collection of biological samples, laboratory techniques involving routine hematology and platelet activity, flow cytometry, western blot, immunocytochemistry, immunofluorescence microscopy, ELISA, spectrophotometry and other laboratory experiments involving human as well as animal specimens. Considering research involving blood contacting biomedical devices especially CF-LVAD and cardiovascular health during the period of last few years at United States, I published 11 full length peer reviewed original research articles (9 first authored) and some of other publications are awaiting. My longterm goal is to advance the understanding of biomedical device-induced (shear stress) blood cell dysfunction and to use this knowledge to guide clinical practice and the design improvement of biomedical devices. My research will result in new knowledge of oxidative stress and of non-physiological shear induced bleeding, infection-like condition and stroke associated with CF-LVADs. The knowledge can be used by clinicians to refine bleeding/infection/stroke risk stratification and mitigation in patients or by engineers to develop less traumatic, biocompatible CF-LVADs.