Diverse insulin-like peptides in Caenorhabditis elegans
Main Article Content
Abstract
Peptide hormones are conserved in living organisms to modulate homeostasis. To elucidate molecular mechanisms in the synthesis, secretion, and functions of peptide hormones, model organisms have been used. Caenorhabditis elegans, one of model organisms, is a good tool since: 1) genome size of the worm is small with over 40% homology to human genome, 2) numerous genetics methods are available, and 3) the worms are transparent throughout the life cycle, so that the secretion of peptide hormones can be followed at cellular level in living preparations by Green Fluorescent Protein tagged peptides. This review reports the structures, physiological functions, and secretion of insulin-like peptides, one family of peptide hormones, with our latest findings in the model organism, Caenorhabditis elegans.
Article Details
How to Cite
MATSUNAGA, Yohei; IWASAKI, Takashi; KAWANO, Tsuyoshi.
Diverse insulin-like peptides in Caenorhabditis elegans.
International Biology Review, [S.l.], v. 1, n. 1, may 2017.
ISSN 2572-7168.
Available at: <https://esmed.org/MRA/ibr/article/view/1276>. Date accessed: 20 apr. 2024.
doi: https://doi.org/10.18103/ibr.v1i1.1276.
Keywords
Caenorhabditis elegans; insulin-like peptides; physiological function; secretion; structure
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References
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8. Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 15 (6) 2001, 672-686.
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15. Barbieri M, Bonafè M, Franceschi C, Paolisso G. Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab. 285 (5) 2003, 1064-1071.
16. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277 (5328) 1997, 942-946.
17. Kawano T, Takuwa K, Nakajima T, Kimura Y. Insulin-like peptides of C. elegans. Worm Breeder’s Gazette 15 (2) 1998, 47.
18. Duret L, Guex N, Peitsch MC, Bairoch A. New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling. Genome Res. 8 (4) 1998, 348-353.
19. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol. 215 (3) 1990, 403-410.
20. Pearson WR, Lipman DJ. Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A. 85 (8) 1988, 2444-2448.
21. Eddy SR1, Mitchison G, Durbin R. Maximum discrimination hidden Markov models of sequence consensus. J Comput Biol. 2 (1) 1995, 9-23.
22. Orci L, Ravazzola M, Storch MJ, Anderson RG, Vassalli JD, Perrelet A. Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell 49 (6) 1987, 865–868
23. Malide D, Seidah NG, Chretien M, Bendayan M. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. J Histo Cyto. 43 (1) 1995, 11–19
24. Thacker C, Rose AM. A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family. Bioessays 22 (6) 2000, 545-553.
25. Thacker C, Srayko M, Rose AM. Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans. Gene 252 (1-2) 2000, 15-25.
26. Kass J, Jacob TC, Kim P, Kaplan JM. The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. J Neurosci. 21 (23) 2001, 9265-9272.
27. Hung WL, Hwang C, Gao S, Liao EH, Chitturi J, Wang Y, Li H, Stigloher C, Bessereau JL, Zhen M. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J 32 (12) 2013, 1745-1760.
28. Hung WL, Wang Y, Chitturi J, Zhen M. A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Development 141 (8) 2014, 1767-1779.
29. Salzberg Y, Ramirez-Suarez NJ, Bülow HE. The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans. PLoS Genet. 10 (9) 2014, e1004657.
30. Polex-Wolf J, Yeo GS, O'Rahilly S. Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome? J Clin Invest. 127 (1) 2017, 98-99.
31. Kawano T, Ito Y, Ishiguro M, Takuwa K, Nakajima T, Kimura Y. Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 273 (2) 2000, 431-436.
32. Matsunaga Y, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T. Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18. Biochem. Biophys. Res. Commun. 423 (3) 2012, 478-483
33. Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382 (6591) 1996, 536-539.
34. Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12 (16) 1998, 2488-2498.
35. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13 (11) 1999, 1438-1452.
36. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389 (6654) 1997, 994-999.
37. Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol. 11 (24) 2001, 1975-1980.
38. Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 11 (24) 2001, 1950-1957.
39. Lin K, Hsin H, Libina N, Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet. 28 (2) 2001, 139-145.
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