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DRUG RELEASE FROM COLLOIDAL-COATED MICRO- OR NANO- CAPSULES

Nily Dan

Abstract


Self-assembly of colloidal particles at liquid/liquid interfaces leads to the formation of mesoporous shells that can be used to coat nano- and micro drug carreirs: Pickering emulsions are composed of a hydrophobic core that delivers oil-soluble drugs, while the aqueous core of colloidosomes allows delivery of hydrophilic drugs. Various studies investigated such carriers as drg delivery systems, finding that the rate of drug release depends on the shell properties. This paper presents the results of Monte-Carlo simulations of the release of encapsulated molecules from such microcapsules, and examines the validity of a previously-developed analytical model.

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References


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